CPC C07D 471/04 (2013.01) [C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 455/02 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01)] | 8 Claims |
1. A compound of formula II:
![]() in which:
R1 is selected from:
![]() R2 and R3 together with the nitrogen to which both R2 and R3 are attached form a ring selected from piperidinyl, piperazinyl, 2-oxa-8-azaspiro[4.5]decan-8-yl, 8-azaspiro[4.5]decan-8-yl and pyrrolidinyl; wherein said pyrrolidinyl, piperazinyl, 2-oxa-8-azaspiro[4.5]decan-8-yl, 8-azaspiro[4.5]decan-8-yl or piperidinyl is unsubstituted or substituted with 1 to 3 groups independently selected from amino, methyl, ethyl, amino-methyl, methyl-amino, hydroxyl, cyano, fluoro-methyl, fluoro and ((((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)amino)methyl;
R4 is selected from hydroxyl, C1-3alkoxy and OC(O)C1-3 alkyl;
R5 is selected from H and methyl;
R6 is selected from hydrogen, methyl and phenyl;
R7 is selected from hydrogen, methyl, ethyl, phenyl and benzyl;
R8 is selected from hydrogen and methyl;
Y1 is selected from N and CH;
Y2 is selected from N and CH;
Y3 is selected from NH and CH2;
Y4 is selected from N and CH;
Y5 is selected from N and CH; or a pharmaceutically acceptable salt thereof.
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