US 11,905,281 B2
KRAS G12C inhibitors and methods of using the same
Brian Alan Lanman, Thousand Oaks, CA (US); Jian Chen, Thousand Oaks, CA (US); Anthony B. Reed, Thousand Oaks, CA (US); Victor J. Cee, Thousand Oaks, CA (US); Longbin Liu, Thousand Oaks, CA (US); David John Kopecky, Thousand Oaks (CA); Patricia Lopez, Thousand Oaks, CA (US); Ryan Paul Wurz, Thousand Oaks, CA (US); Thomas T. Nguyen, Thousand Oaks, CA (US); Shon Booker, Thousand Oaks, CA (US); Nobuko Nishimura, Thousand Oaks, CA (US); Youngsook Shin, Thousand Oaks, CA (US); Nuria A. Tamayo, Thousand Oaks, CA (US); John Gordon Allen, Thousand Oaks, CA (US); and Jennifer Rebecca Allen, Thousand Oaks, CA (US)
Assigned to Amgen Inc., Thousand Oaks, CA (US)
Filed by Amgen Inc., Thousand Oaks, CA (US)
Filed on Sep. 24, 2020, as Appl. No. 17/031,607.
Application 17/031,607 is a continuation of application No. 16/661,907, filed on Oct. 23, 2019, abandoned.
Application 16/661,907 is a continuation of application No. 15/984,855, filed on May 21, 2018, granted, now 10,519,146, issued on Dec. 31, 2019.
Claims priority of provisional application 62/509,629, filed on May 22, 2017.
Prior Publication US 2021/0009577 A1, Jan. 14, 2021
Int. Cl. C07D 471/04 (2006.01); C07D 213/82 (2006.01); C07D 417/04 (2006.01); A61K 38/07 (2006.01); C07D 487/08 (2006.01); C07D 417/12 (2006.01); C07D 513/04 (2006.01); C07D 487/10 (2006.01); C07D 487/04 (2006.01); C07D 401/04 (2006.01); C07D 239/80 (2006.01); C07D 401/14 (2006.01); C07D 237/34 (2006.01); C07D 403/04 (2006.01); A61K 31/496 (2006.01); A61K 31/416 (2006.01); A61K 31/55 (2006.01); A61K 31/454 (2006.01); A61K 31/519 (2006.01); A61K 31/502 (2006.01); A61K 31/517 (2006.01); A61K 31/5025 (2006.01); A61P 35/00 (2006.01); A61K 31/7068 (2006.01); C07D 275/04 (2006.01); C07D 475/00 (2006.01)
CPC C07D 417/04 (2013.01) [A61K 31/416 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 31/7068 (2013.01); A61K 38/07 (2013.01); A61P 35/00 (2018.01); C07D 237/34 (2013.01); C07D 239/80 (2013.01); C07D 275/04 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 475/00 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 513/04 (2013.01)] 16 Claims
 
1. A compound, wherein the compound is selected from:

OG Complex Work Unit Chemistry