CPC C07D 405/04 (2013.01) [C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01)] | 11 Claims |
1. A compound represented by formula (III) or a pharmaceutically acceptable salt thereof,
wherein,
is selected from a single bond and a double bond;
T1 is selected from C(R4) and N;
ring A is selected from phenyl, pyridyl and thienyl;
R1 is selected from H, F, Cl, Br and I;
R2 is selected from H, F, Cl, Br, I, OH, NH2 and OCH3;
L1 is selected from a bond, —(CR5)n—, —O(CR5)n—, —S(CR5)n—, —NH(CR5)n—, #—NHCO—, —CONHCH2—, —SOCH2—, —SO2CH2—, —NHSO2—, —CH═CH—, —N═C(Ph)-, —O-cyclobutyl-, —O-cyclopentyl-, —CO-piperazinyl-, and —SO2-piperazinyl-;
R3 is selected from H, F, Cl, Br, I, OH, NH2, CN, COOH, NHCOOH, COOC1-4 alkyl, C1-3 alkyl, C1-3 alkoxy, C2-3 alkenyl, phenyl, pyridyl, tetrahydropyranyl,
and the COOH, NHCOOH, COOC1-4 alkyl, C1-3 alkyl, C1-3 alkoxy, C2-3 alkenyl, phenyl, pyridyl, tetrahydropyranyl,
are optionally substituted by 1, 2, or 3 Ra;
R4 is selected from H, F, Cl, Br, I and CH3;
R5 is selected from H, F, Cl, Br and I;
Ra is selected from H, F, Cl, Br, I, OH, NRR′, CN, C1-4 alkyl, C1-3 alkoxy, COOCH3, CONH2 and
R and R′ are each independently selected from H and CH3;
n is selected from 1, 2, 3;
a site with “#” is the site connected with R3 group.
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