CPC C07D 231/18 (2013.01) | 22 Claims |
1. A compound of formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Q is selected from O or S;
V, X and Y are each independently selected from C and N, and W and Z are each independently selected from N, O, S, NH and CH, provided that at least one of V, W, X, Y and Z is N, O, S or NH;
RX and RY are each independently a halo, —OH, —NO2, —NH2, —N3, —SH, —SO2H, —SO2NH, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton;
optionally RX and RY together with the atoms X and Y to which they are attached may form a 4- to 12-membered saturated or unsaturated cyclic group fused to ring A, wherein the cyclic group fused to ring A may optionally be substituted;
m is 0, 1 or 2;
each R1 is independently a halo, —OH, —NO2, —NH2, —N3, —SH, —SO2H, —SO2NH, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton;
optionally RX and any R1 attached to W may together with the atoms W and X to which they are attached form a 4- to 12-membered saturated or unsaturated cyclic group fused to ring A, wherein the cyclic group fused to ring A may optionally be substituted;
optionally RY and any R1 attached to Z may together with the atoms Y and Z to which they are attached form a 4- to 12-membered saturated or unsaturated cyclic group fused to ring A, wherein the cyclic group fused to ring A may optionally be substituted; and
R2 is selected from:
(i) a group having the formula:
wherein R20 is a halo, —OH, —NO2, —NH2, —N3, —SH, —SO2H, —SO2NH, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton; or
(ii) a heteroaryl group substituted at the α and α′ positions, wherein R2 may optionally be further substituted.
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