CPC C07D 213/74 (2013.01) [A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0031 (2013.01); A61K 9/0048 (2013.01); A61K 9/0056 (2013.01); A61K 9/0078 (2013.01); A61K 9/0095 (2013.01); A61K 9/02 (2013.01); A61K 9/06 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 31/00 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/20 (2013.01); A61K 47/38 (2013.01); C07D 213/75 (2013.01); C07D 241/20 (2013.01); C07D 401/04 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 493/10 (2013.01); C07D 495/04 (2013.01)] | 17 Claims |
1. A compound having the structure of Formula (VI):
![]() wherein:
R′1 is
![]() L2 is —NH—C(═O)—, or —C(═O)NH—;
X is CR3 or N;
Y is independently selected from CR9 or N;
R2 is C1-C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, C1-C4alkyleneC2-C8heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl; wherein C1-C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, C1-C4alkyleneC2-C8heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl is optionally substituted with at least one R3;
R3 is independently selected from H, F, D, Cl, Br, I, —CN, —NO2, —OH, —CF3, —OCF3, —OR5, C1-C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl,
n is an integer selected from 0-2;
R9 is independently selected from H, D, halogen, C1-C6alkyl, C1-C6haloalkyl, —OR5, —OCF3, C1-C6 carbonylalkyl, or —CF3; or two R9 attached to the same carbon atom form an oxetane ring;
R10 is selected from halogen, C1-C6alkyl, C1-C6haloalkyl, —OR5, —OCF3, C1-C6 carbonylalkyl, or —CF3;
R5 is independently selected from H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.
|