US 11,905,230 B2
Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament
Hai Qian, Nanjing (CN); Wenlong Huang, Nanjing (CN); Chunxia Liu, Nanjing (CN); and Jianyong Yang, Nanjing (CN)
Assigned to CHINA PHARMACEUTICAL UNIVERSITY, Nanjing (CN)
Appl. No. 16/617,409
Filed by CHINA PHARMACEUTICAL UNIVERSITY, Nanjing (CN)
PCT Filed May 24, 2018, PCT No. PCT/CN2018/088204
§ 371(c)(1), (2) Date Nov. 26, 2019,
PCT Pub. No. WO2018/219204, PCT Pub. Date Dec. 6, 2018.
Claims priority of application No. 201710407580.X (CN), filed on May 27, 2017.
Prior Publication US 2021/0122704 A1, Apr. 29, 2021
Int. Cl. C07C 229/42 (2006.01); C07C 255/49 (2006.01); C07C 317/28 (2006.01); C07D 261/08 (2006.01); C07C 255/59 (2006.01)
CPC C07C 229/42 (2013.01) [C07C 255/59 (2013.01); C07C 317/28 (2013.01); C07D 261/08 (2013.01)] 2 Claims
 
1. A compound is selected from the group consisting of
2-(4-((2′-chloro-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-2),
2-(4-((2′-methoxy-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-6),
2-(4-((2′-nitrile-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-7),
2-(4-((2′-trifluoromethyl-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-8),
2-(4-(([1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-11),
2-(4-((2′-chloro-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-24),
2-(4-((2′-trifluoromethyl-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-28),
2-(4-((4′-trifluoromethoxy-2′,6′-dimethyl-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-29),
2-(4-(((4′-ethoxy-2′-methyl-[1,1′-biphenyl]-3-yl)methylene)amino)phenoxy)acetic acid (I-31),
2-(4-((2′-trifluoromethoxy-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-32),
2-(4-((2′-trifluoromethoxy-[1,1′-biphenyl]-3-methylene)amino-2-fluoro)phenoxy)acetic acid (I-33),
2-(4-((4′-trifluoromethoxy-2′,6′-dimethyl-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-34),
2(4-(((4′-(hexyloxy)-2′,6′-dimethyl-[1,1′-biphenyl]-3-yl)methyl)amino)phenoxy)acetic acid (I-43), and
2(4-(((4′-(cyclohexyloxy)-2′,6′-dimethyl-[1,1′-biphenyl]-3-yl)methyl)amino)phenoxy)acetic acid (I-45).