US 11,904,581 B2
Bifunctional film
Hsin-Hsin Shen, Zhudong Township (TW); Yu-Chi Wang, New Taipei (TW); Ming-Chia Yang, Zhudong Township (TW); Yu-Bing Liou, Hsinchu (TW); Wei-Hong Chang, Linnei Township (TW); Yun-Han Lin, Taichung (TW); Hsin-Yi Hsu, Taoyuan (TW); Yun-Chung Teng, Kaohsiung (TW); Chia-Jung Lu, Taichung (TW); Yi-Hsuan Lee, Taipei (TW); Jian-Wei Lin, Tainan (TW); Kun-Mao Kuo, Tainan (TW); and Ching-Mei Chen, Tainan (TW)
Assigned to INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Hsinchu (TW)
Filed by Industrial Technology Research Institute, Hsinchu (TW)
Filed on Aug. 11, 2022, as Appl. No. 17/885,874.
Application 17/885,874 is a division of application No. 16/675,838, filed on Nov. 6, 2019, granted, now 11,458,715.
Claims priority of provisional application 62/756,777, filed on Nov. 7, 2018.
Prior Publication US 2022/0388293 A1, Dec. 8, 2022
Int. Cl. B32B 27/36 (2006.01); B32B 27/24 (2006.01); B32B 27/30 (2006.01); B05D 7/00 (2006.01); B05D 5/08 (2006.01); B32B 38/00 (2006.01); B32B 37/02 (2006.01); B32B 38/16 (2006.01); B32B 37/26 (2006.01)
CPC B32B 27/36 (2013.01) [B05D 5/08 (2013.01); B05D 7/544 (2013.01); B05D 7/584 (2013.01); B32B 27/24 (2013.01); B32B 27/306 (2013.01); B32B 37/02 (2013.01); B32B 37/26 (2013.01); B32B 38/164 (2013.01); B32B 2038/168 (2013.01); B32B 2307/728 (2013.01); B32B 2307/73 (2013.01); B32B 2535/00 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A bifunctional film, comprising:
an anti-adhesion layer; and
an attachment layer over the anti-adhesion layer,
wherein the anti-adhesion layer comprises a first polymer mixture, and the first polymer mixture comprises:
a first hydrophobic polymer which is at least one hydrophobic polymer selected from the group consisting of: polycaprolactone (PCL), polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), poly(glycolic acid) (PGA), polyhydroxybutyrate (PHB), polydioxanone (PDS), poly(propylene fumarate) (PPF), polyanhydrides, polyacetals, poly(ortho esters), polycarbonates, polyurethanes, polyphosphazenes and polyphosphoester; and
a first hydrophilic polymer which is at least one hydrophilic polymer selected from the group consisting of: hyaluronic acid (HA), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), a derivative of polyethylene glycol and poly(ethylene oxide) (PEO), and
in the anti-adhesion layer, a weight ratio of the first hydrophobic polymer to the first hydrophilic polymer is 1:0.01-1,
wherein the anti-adhesion layer is formed by a step of drying a first polymer solution to form a film, and the first polymer solution comprises a first hydrophobic solution and a first hydrophilic solution, and the solute of the first hydrophobic solution is the first hydrophobic polymer, and the solute of the first hydrophilic solution is the first hydrophilic polymer,
wherein the attachment layer consists of a second hydrophilic polymer, and the second hydrophilic polymer is at least one hydrophilic polymer selected from the group consisting of: gelatin, a modified gelatin, alginate, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), a derivative of polyethylene glycol, collagen, demineralized bone matrix (DBM), bone morphogenetic protein (BMP), albumin, chitosan, fibrin, polyoxyethylene and polyvinylpyrrolidone, and
wherein the attachment layer is formed by a step of drying a second polymer solution over the anti-adhesion layer to form a film, and the second polymer solution consists of a second hydrophilic solution, and the solute of the second hydrophilic solution is the second hydrophilic polymer.