	US 11,904,312 B2
	Microfluidic devices with lid for loading fluid
Hilary Ely, Corvallis, OR (US); Adam Higgins, Corvallis, OR (US); Rachel M. White, Corvallis, OR (US); Erik D. Torniainen, Corvallis, OR (US); Tod Woodford, Corvallis, OR (US); Michael W. Cumbie, Corvallis, OR (US); and Chien-Hua Chen, Corvallis, OR (US)
Assigned to Hewlett-Packard Development Company, L.P., Spring, TX (US)
Appl. No. 16/643,264
Filed by Hewlett-Packard Development Company, L.P., Spring, TX (US)
PCT Filed Nov. 22, 2017, PCT No. PCT/US2017/062925 § 371(c)(1), (2) Date Feb. 28, 2020, PCT Pub. No. WO2019/103729, PCT Pub. Date May 31, 2019.
Prior Publication US 2020/0206734 A1, Jul. 2, 2020
Int. Cl. B01L 3/00 (2006.01); B81B 1/00 (2006.01)

CPC B01L 3/502715 (2013.01) [B01L 3/50273 (2013.01); B01L 3/502723 (2013.01); B01L 2300/041 (2013.01); B01L 2300/048 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/12 (2013.01); B01L 2300/18 (2013.01); B01L 2400/0406 (2013.01); B81B 1/00 (2013.01)]

13 Claims

1. A microfluidic device, comprising:

a substrate;

a lid mounted to the substrate and forming a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate, said lid comprising an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action; and

a microchip mounted to the substrate, a portion of the microchip positioned within the discrete microfluidic chamber and a second portion of the microchip positioned outside of the discrete microfluidic chamber;

wherein the lid further comprises an exterior surface modification selected from of a Fresnel lens, a crenulated surface, a non-uniform thickness, a thin film optical filter, or a combination thereof; the lid comprises an interior modification to enhance surface wetting; or the microchip comprises an exterior modification; or a combination thereof.