US 11,904,139 B2
Closed-loop control in steady-state conditions
Benyamin Grosman, Winnetka, CA (US); Louis J. Lintereur, Boise, ID (US); Anirban Roy, Agoura Hills, CA (US); Neha J. Parikh, West Hills, CA (US); Di Wu, Glendale, CA (US); Patrick E. Weydt, Moorpark, CA (US); David Dunleavy, West Hills, CA (US); and Ali Dianaty, Porter Ranch, CA (US)
Assigned to Medtronic MiniMed, Inc., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Apr. 5, 2021, as Appl. No. 17/222,570.
Prior Publication US 2022/0313908 A1, Oct. 6, 2022
Int. Cl. A61M 5/172 (2006.01)
CPC A61M 5/1723 (2013.01) [A61M 2205/52 (2013.01); A61M 2230/201 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A processor-implemented method for closed-loop control in steady-state conditions, the method comprising:
determining, based on data including historical bolus information but excluding historical basal information, an amount of unmetabolized therapeutic substance in a patient;
determining, based on a difference between a most recent measurement of a physiological condition of the patient and a target value for the physiological condition, a first amount or rate of a basal dosage for delivery to the patient;
adjusting, based on the amount of unmetabolized therapeutic substance, the first amount or rate of the basal dosage to determine a second amount or rate of the basal dosage; and
causing delivery of the second amount or rate of the basal dosage based on communicating the second amount or rate in a delivery command.
 
8. A system for closed-loop control in steady-state conditions, the system comprising:
one or more processors; and
one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause performance of:
determining, based on data including historical bolus information but excluding historical basal information, an amount of unmetabolized therapeutic substance in a patient;
determining, based on a difference between a most recent measurement of a physiological condition of the patient and a target value for the physiological condition, a first amount or rate of a basal dosage for delivery to the patient;
adjusting, based on the amount of unmetabolized therapeutic substance, the first amount or rate of the basal dosage to determine a second amount or rate of the basal dosage; and
causing delivery of the second amount or rate of the basal dosage based on communicating the second amount or rate in a delivery command.
 
15. One or more non-transitory processor-readable storage media storing instructions which, when executed by one or more processors, cause performance of:
determining, based on data including historical bolus information but excluding historical basal information, an amount of unmetabolized therapeutic substance in a patient;
determining, based on a difference between a most recent measurement of a physiological condition of the patient and a target value for the physiological condition, a first amount or rate of a basal dosage for delivery to the patient;
adjusting, based on the amount of unmetabolized therapeutic substance, the first amount or rate of the basal dosage to determine a second amount or rate of the basal dosage; and
causing delivery of the second amount or rate of the basal dosage based on communicating the second amount or rate in a delivery command.