	US 11,904,070 B2
	Tissue scaffold and scaffold composition
Antonio Leonardi, Nottingham (GB); Helen Celia Cox, Nottingham (GB); Robin Andrew Quirk, Nottingham (GB); and Kevin Morris Shakesheff, Nottingham (GB)
Assigned to LOCATE THEAPEUTICS LIMITED, Nottingham (GB)
Appl. No. 16/485,882
Filed by Locate Therapeutics Limited, Nottingham (GB)
PCT Filed Feb. 12, 2018, PCT No. PCT/GB2018/050381 § 371(c)(1), (2) Date Aug. 14, 2019, PCT Pub. No. WO2018/150166, PCT Pub. Date Aug. 23, 2018.
Claims priority of application No. 1702475 (GB), filed on Feb. 15, 2017.
Prior Publication US 2020/0368387 A1, Nov. 26, 2020
Int. Cl. A61L 27/26 (2006.01); A61L 27/18 (2006.01); A61L 27/10 (2006.01); A61L 27/12 (2006.01); A61L 27/38 (2006.01); A61K 38/18 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01)

CPC A61L 27/26 (2013.01) [A61K 38/1875 (2013.01); A61L 27/10 (2013.01); A61L 27/12 (2013.01); A61L 27/18 (2013.01); A61L 27/38 (2013.01); A61L 27/502 (2013.01); A61L 27/54 (2013.01); A61L 2300/252 (2013.01); A61L 2300/62 (2013.01); A61L 2430/02 (2013.01); A61L 2430/12 (2013.01); A61L 2430/38 (2013.01)]

35 Claims

1. A scaffold material composition for forming a solid tissue scaffold, the composition comprising a plurality of hollow polymer pellets, each hollow polymer pellet comprising an open lumen extending through the pellet, wherein the lumen volume is at least 10% of each hollow polymer pellet,

wherein the hollow polymer pellets have a tubular structure, with the lumen extending therethrough, or wherein the hollow polymer pellets have a tubular structure and the lumen is in the form of a channel running through the pellet structure, whereby the channel is open substantially along its length,

wherein the hollow pellets are 50-700 microns in length,

wherein the plurality of hollow polymer pellets are capable of interlinking and setting into a solid scaffold, and

wherein the scaffold material has a porosity of at least about 55%.