US 11,904,069 B2
Mg alloy mesh reinforced polymer/ECM hybrid scaffolds for critical-sized bone defect regeneration
William R. Wagner, Gibsonia, PA (US); Sang-Ho Ye, Cheswick, PA (US); Yingqi Chen, Pittsburgh, PA (US); and Vesselin Shanov, Cincinnati, OH (US)
Assigned to UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US); and UNIVERSITY OF CINCINNATI, Cincinnati, OH (US)
Appl. No. 16/498,035
Filed by UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US); and UNIVERSITY OF CINCINNATI, Cincinnati, OH (US)
PCT Filed Apr. 4, 2018, PCT No. PCT/US2018/025997
§ 371(c)(1), (2) Date Sep. 26, 2019,
PCT Pub. No. WO2018/187407, PCT Pub. Date Oct. 11, 2018.
Claims priority of provisional application 62/481,206, filed on Apr. 4, 2017.
Prior Publication US 2021/0187158 A1, Jun. 24, 2021
Int. Cl. A61L 27/04 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/44 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/047 (2013.01) [A61L 27/34 (2013.01); A61L 27/3608 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61L 27/44 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 2400/12 (2013.01); A61L 2420/02 (2013.01); A61L 2430/02 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A biomimetic, biodegradable scaffold, comprising:
a polymer/demineralized bone matrix composite, the composite comprising:
polymer fibers selected from the group consisting of nanofibers, microfibers, and combinations thereof, comprising poly(lactic-co-glycolic acid); and
an extracellular demineralized bone matrix derived from a precursor solution comprising demineralized bone matrix suspended in hyaluronic acid, applied to the polymer fibers; and
a mesh substrate comprising an etched magnesium alloy foil, embedded in the composite or encapsulated by the composite and effective to release Mg ions to stimulate bone regeneration,
wherein the composite is a porous and an interconnected fiber structure,
wherein the scaffold stimulates bone tissue regeneration for calvarial critical sized defects, absent of an exogenous growth factor, and
wherein the scaffold has a flexural modulus of greater than 500 MPa to at least 560 MPa.