	US 11,904,053 B2
	Dry powder formulations of thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of use thereof
Catherine Eugenie Chaillan Huntington, Cambridge (GB); Susan Hoe, San Francisco, CA (US); Prakash Manikwar, Gaithersburg, MD (US); Roland Wilhelm Kolbeck, Gaithersburg, MD (US); Emma Suzanne Cohen, Cambridge (GB); David Lechuga-Ballesteros, San Francisco, CA (US); Kellisa Beth Hansen, San Francisco, CA (US); Dexter Joseph D'Sa, San Francisco, CA (US); and Saba Ghazvini, Gaithersburg, MD (US)
Assigned to MEDIMMUNE LIMITED, Cambridge (GB)
Filed by MedImmune Limited, Cambridge (GB)
Filed on Oct. 27, 2020, as Appl. No. 17/081,821.
Claims priority of provisional application 62/926,833, filed on Oct. 28, 2019.
Prior Publication US 2021/0121406 A1, Apr. 29, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 39/00 (2006.01); A61K 47/26 (2006.01); A61K 9/00 (2006.01); C07K 16/24 (2006.01); C07K 14/54 (2006.01)

CPC A61K 9/1623 (2013.01) [A61K 9/0075 (2013.01); A61K 9/1652 (2013.01); C07K 16/244 (2013.01); C07K 2317/24 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01)]

19 Claims

1. A dry powder formulation comprising a plurality of microparticles, the microparticles comprising:

a. about 8% to about 11% leucine by weight;

b. about 2% to about 4% trileucine by weight; and

c. an antigen binding fragment of an anti-thymic stromal lymphopoietin (TSLP) antibody comprising:

a heavy chain variable domain comprising:

i. a heavy chain CDR1 sequence consisting of the amino acid sequence set forth in SEQ ID NO:1;

ii. a heavy chain CDR2 sequence consisting of the amino acid sequence set forth in SEQ ID NO:2; and

iii. a heavy chain CDR3 sequence consisting of the amino acid sequence set forth in SEQ ID NO:3, and

a light chain variable domain comprising:

i. a light chain CDR1 sequence consisting of the amino acid sequence set forth in SEQ ID NO:5;

ii. a light chain CDR2 sequence consisting of the amino acid sequence set forth in SEQ ID NO:6, and

iii. a light chain CDR3 sequence consisting of the amino acid sequence set forth in SEQ ID NO:7.