US 11,904,045 B2
Low power, chemically amplified, electrically removable barrier
Samson Chen, Pasadena, CA (US); Axel Scherer, Pasadena, CA (US); and Richard Daniel Smith, Jr., Pasadena, CA (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed by CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed on May 14, 2021, as Appl. No. 17/321,296.
Application 17/321,296 is a division of application No. 16/044,124, filed on Jul. 24, 2018, granted, now 11,304,893.
Claims priority of provisional application 62/536,062, filed on Jul. 24, 2017.
Prior Publication US 2021/0322300 A1, Oct. 21, 2021
Int. Cl. A61B 5/00 (2006.01); A61K 9/00 (2006.01); A61B 5/145 (2006.01); A61J 1/14 (2023.01)
CPC A61K 9/0009 (2013.01) [A61B 5/14532 (2013.01); A61B 5/4839 (2013.01); A61B 5/686 (2013.01); A61J 1/1412 (2013.01); A61J 1/1468 (2015.05); A61K 9/0024 (2013.01); A61K 9/0097 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A device, comprising:
a container having an opening;
a plurality of barriers closing the opening; and
a chemical compound or biological material within the container,
wherein:
the device is configured to be implantable within a human body or other organism,
the plurality of barriers is configured to electrochemically or electrothermally unseal, upon application of an electric potential or current to at least one barrier of the plurality of barriers, thereby allowing interaction between the chemical compound or biological material and the human body or other organism,
the plurality of barriers comprises:
a first barrier,
a second barrier having a greater mechanical stability than the first barrier and placed between the first barrier and the chemical compound or biological material, the second barrier being configured to electrochemically or mechanically unseal upon contact with the chemical compound, and
a third barrier placed between the second barrier and the chemical compound or biological material, the third barrier being not reactive to the chemical compound or biological material and being configured to electrochemically or electrothermally unseal when a current is applied to the third barrier, and
the first barrier is not reactive to the human body or other organism and is configured to mechanically break when the second barrier is electrochemically unsealed.