US 11,904,004 B2
Anti-CD277 antibodies
Daniel Olive, Marseilles (FR); Marc Bonneville, Nantes (FR); Emmanuel Scotet, Nantes (FR); Christelle Harly, Nantes (FR); and Yves Guillaume, Marseilles (FR)
Assigned to INSERM, Paris (FR); UNIVERSITE D'AIX-MARSEILLE, Marseilles (FR); INSTITUT JEAN PAOLI & IRENE CALMETTES, Marseill (FR); CNRS, Paris (FR); and UNIVERSITE DE NANTES, Nantes (FR)
Filed by INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); UNIVERSITE D'AIX-MARSEILLE, Marseilles (FR); INSTITUT JEAN PAOLI & IRENE CALMETTES, Marseilles (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); and UNIVERSITE DE NANTES, Nantes (FR)
Filed on Jun. 9, 2020, as Appl. No. 16/896,556.
Application 16/896,556 is a continuation of application No. 16/283,733, filed on Feb. 22, 2019, granted, now 10,716,838.
Application 16/283,733 is a continuation of application No. 14/791,528, filed on Jul. 6, 2015, abandoned.
Application 14/791,528 is a continuation in part of application No. 13/994,277, abandoned, previously published as PCT/EP2011/072787, filed on Dec. 14, 2011.
Claims priority of application No. PCT/IB2010/003417 (WO), filed on Dec. 15, 2010.
Prior Publication US 2020/0376104 A1, Dec. 3, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); C07K 16/28 (2006.01)
CPC A61K 39/001129 (2018.08) [C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 39/00 (2013.01); C07K 2317/55 (2013.01); C07K 2317/74 (2013.01); C07K 2317/75 (2013.01)] 11 Claims
 
1. A nucleic acid encoding at least the VH and VL domains of the anti-CD277 antibody, wherein said nucleic acid comprising the coding sequences of the following CDRs:
 
 
 
 
Amino acid sequence
 
 
 
H-CDR1 RYYMY (SEQ ID NO: 27)
 
 
 
H-CDR2 EINPNNGGTKFNEKFKN (SEQ ID
 
 
NO: 28)
 
 
 
H-CDR3 EDDYDGTPFAMDY (SEQ ID
 
 
NO: 29)
 
 
 
L-CDR1 HASQNINVWLS (SEQ ID NO: 30)
 
 
 
L-CDR2 KASNLHT (SEQ ID NO: 31)
 
 
 
L-CDR3 QQGQTYPYT (SEQ ID NO: 32)