US 11,903,707 B2
Enclosed desorption electrospray ionization probes and method of use thereof
Robert Graham Cooks, West Lafayette, IN (US); Zheng Ouyang, West Lafayette, IN (US); Chien-hsun Chen, West Lafayette, IN (US); Ziqing Lin, West Lafayette, IN (US); and Livia Schiavinato Eberlin, Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on Mar. 11, 2022, as Appl. No. 17/692,613.
Application 17/692,613 is a continuation of application No. 17/066,727, filed on Oct. 9, 2020, granted, now 11,304,637.
Application 17/066,727 is a continuation of application No. 16/720,991, filed on Dec. 19, 2019, granted, now 10,799,165.
Application 16/720,991 is a continuation of application No. 16/539,562, filed on Aug. 13, 2019, granted, now 10,555,694.
Application 16/539,562 is a continuation of application No. 16/248,066, filed on Jan. 15, 2019, granted, now 10,420,495, issued on Sep. 24, 2019.
Application 16/248,066 is a continuation of application No. 15/989,706, filed on May 25, 2018, granted, now 10,213,143, issued on Feb. 26, 2019.
Application 15/989,706 is a continuation of application No. 15/617,013, filed on Jun. 8, 2017, granted, now 10,004,440, issued on Jun. 26, 2018.
Application 15/617,013 is a continuation of application No. 15/400,358, filed on Jan. 6, 2017, granted, now 9,700,251, issued on Jul. 11, 2017.
Application 15/400,358 is a continuation of application No. 14/688,496, filed on Apr. 16, 2015, granted, now 9,538,945, issued on Jan. 10, 2017.
Application 14/688,496 is a continuation of application No. 13/486,824, filed on Jun. 1, 2012, granted, now 9,024,254, issued on May 5, 2015.
Claims priority of provisional application 61/492,948, filed on Jun. 3, 2011.
Prior Publication US 2022/0265172 A1, Aug. 25, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1477 (2006.01); A61B 10/00 (2006.01); H01J 49/04 (2006.01); A61M 11/00 (2006.01); A61M 25/00 (2006.01); H01J 49/00 (2006.01); H01J 49/16 (2006.01); H01J 49/34 (2006.01); G01N 33/483 (2006.01); A61B 5/145 (2006.01); A61B 5/15 (2006.01); A61B 5/157 (2006.01); G01N 1/02 (2006.01)
CPC A61B 5/1477 (2013.01) [A61B 10/0045 (2013.01); A61M 11/00 (2013.01); A61M 25/00 (2013.01); G01N 33/4833 (2013.01); H01J 49/0022 (2013.01); H01J 49/0404 (2013.01); H01J 49/0445 (2013.01); H01J 49/167 (2013.01); H01J 49/34 (2013.01); A61B 5/145 (2013.01); A61B 5/1405 (2013.01); A61B 5/157 (2013.01); A61B 5/150015 (2013.01); A61B 5/150992 (2013.01); A61M 2202/0468 (2013.01); G01N 2001/028 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An ionization device, the device comprising:
an elongate tube comprising a proximal end and open distal end, wherein the elongate tube further comprises an opening in a sidewall located at a distal portion of the elongate tube;
an interface component comprising a first end configured to mate with an inlet of a mass spectrometer and a second end configured to mate with the proximal end of the elongate tube; and
a desorption electrospray ionization (DESI) source comprising a discharge tube;
wherein the device is configured such that the proximal end of the elongate tube is inserted into the second end of the interface component and a portion of the discharge tube is inserted through the sidewall of the elongate tube and terminates prior to the open distal end.