US 11,903,698 B2
Glycemic health metric determination and application
Lane Desborough, Thousand Oaks, CA (US); Cesar C. Palerm, Pasadena, CA (US); and Salman Monirabbasi, Los Angeles, CA (US)
Assigned to Medtronic Minimed, Inc., Northridge, CA (US)
Filed by Medtronic Minimed, Inc., Northridge, CA (US)
Filed on Jul. 10, 2019, as Appl. No. 16/508,196.
Application 16/508,196 is a continuation of application No. 13/710,122, filed on Dec. 10, 2012, granted, now 10,390,740.
Application 13/710,122 is a continuation in part of application No. 13/326,890, filed on Dec. 15, 2011, granted, now 9,445,757, issued on Sep. 20, 2016.
Claims priority of provisional application 61/428,066, filed on Dec. 29, 2010.
Prior Publication US 2020/0000384 A1, Jan. 2, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); G16H 20/17 (2018.01); G16H 50/30 (2018.01); G16H 20/10 (2018.01); G16H 40/63 (2018.01); A61B 5/1473 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/0002 (2013.01); A61B 5/0004 (2013.01); A61B 5/4839 (2013.01); A61B 5/6849 (2013.01); A61B 5/7225 (2013.01); A61B 5/7275 (2013.01); A61B 5/746 (2013.01); G16H 20/10 (2018.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01); G16H 50/30 (2018.01); A61B 5/1451 (2013.01); A61B 5/1473 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An apparatus for use with a patient, with a blood glucose monitoring device, and with an infusion device, the apparatus comprising:
one or more processors configured to:
compute a profile of a blood glucose concentration of the patient based, at least in part, on a probability density function of a plurality of blood glucose concentration values collected at the blood glucose monitoring device;
determine a metric based, at least in part, on a convolution of a cost or loss function and the profile, wherein the metric is for balancing short-term and long-term risks associated with a therapy, and wherein the metric is representative of a glycemic health of the patient, the cost or loss function being based, at least in part, on a log-square operation and being further based, at least in part, on a parameter selected to balance Spearman rank coefficients with hypoglycemic-based metrics and hyperglycemic-based metrics, wherein the log-square operation is applied to at least one of a computed mean of the plurality of blood glucose concentration values or a measure of a statistical dispersion of the plurality of blood glucose concentration values; and
affect an insulin therapy applied to the patient by the infusion device, based, at least in part, on the metric.