US 11,903,570 B2
Devices and methods for treating a vessel in a subject
Sean Cummins, County Limerick (IE); Nigel Phelan, Lucan (IE); Stephen Cox, Dublin (IE); and Martin O'Halloran, Corandulla (IE)
Assigned to National University of Ireland, Galway, Galway (IE)
Filed by National University of Ireland, Galway, Galway (IE)
Filed on May 20, 2019, as Appl. No. 16/416,838.
Claims priority of application No. 18173170 (EP), filed on May 18, 2018.
Prior Publication US 2019/0350567 A1, Nov. 21, 2019
Int. Cl. A61B 17/3207 (2006.01); A61B 17/00 (2006.01); A61B 18/14 (2006.01); A61B 17/22 (2006.01); A61B 17/32 (2006.01); A61B 18/00 (2006.01); A61M 25/00 (2006.01); A61B 17/12 (2006.01)
CPC A61B 17/00008 (2013.01) [A61B 17/3207 (2013.01); A61B 17/320758 (2013.01); A61B 18/1492 (2013.01); A61B 17/1204 (2013.01); A61B 17/12109 (2013.01); A61B 17/12136 (2013.01); A61B 2017/00778 (2013.01); A61B 2017/00867 (2013.01); A61B 2017/22065 (2013.01); A61B 2017/320004 (2013.01); A61B 2017/320008 (2013.01); A61B 2017/320733 (2013.01); A61B 2017/320741 (2013.01); A61B 2018/00404 (2013.01); A61M 25/0082 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of treating a varicose vein in a subject by denuding a lumen of the varicose vein to cause thrombotic occlusion of the varicose vein and subsequent fibrotic closure by the inflammatory response to endothelial and media layer disruption, comprising:
advancing a device distally across a treatment zone in the varicose vein, wherein the device comprises an elongated catheter having a lumen and a distal end, and a radially expansible treatment element disposed in the lumen and configured for axial movement relative to the catheter;
deploying the radially expansible treatment element out of the distal end of the catheter to radially expand and circumferentially impress against a lumen of the varicose vein at a distal end of the treatment zone to cause disruption of the endothelial and medial layers at the treatment zone;
withdrawing the deployed radially expansible treatment element proximally along the treatment zone with the treatment element circumferentially impressed against the lumen of the varicose vein to mechanically and circumferentially denude at least a 10 cm length of the treatment zone of the varicose vein;
recapturing the radially expansible treatment element into the lumen of the elongated catheter; and
withdrawing the device from the treated varicose vein.