US 12,230,403 B2
Techniques for determining acid-base homeostasis
Alhaji Cherif, Kew Gardens, NY (US); Peter Kotanko, New York, NY (US); and Doris Helen Fuertinger, Frankfurt am Main (DE)
Assigned to Fresenius Medical Care Holdings, Inc., Waltham, MA (US)
Filed by Fresenius Medical Care Holdings, Inc., Waltham, MA (US)
Filed on Mar. 11, 2020, as Appl. No. 16/815,366.
Claims priority of provisional application 62/816,446, filed on Mar. 11, 2019.
Prior Publication US 2020/0294676 A1, Sep. 17, 2020
Int. Cl. G16H 50/50 (2018.01); A61M 1/14 (2006.01); G16B 5/00 (2019.01); G16C 10/00 (2019.01); G16C 20/00 (2019.01); G16H 10/60 (2018.01); G16H 20/10 (2018.01); G16H 20/40 (2018.01); G16H 20/60 (2018.01); G16H 50/20 (2018.01)
CPC G16H 50/50 (2018.01) [G16B 5/00 (2019.02); G16C 10/00 (2019.02); G16C 20/00 (2019.02); G16H 10/60 (2018.01); G16H 20/10 (2018.01); G16H 20/40 (2018.01); G16H 20/60 (2018.01); G16H 50/20 (2018.01); A61M 1/14 (2013.01)] 15 Claims
 
1. A method of treating an acid-base disorder of a human patient, the method comprising:
determining at least one treatment recommendation for the acid-base disorder for a population of virtual patients using an acid-base model configured to model the acid-base disorder via modelling serum pH regulation of a human bicarbonate (HCO2)/carbon dioxide (CO2) buffering system using human renal and pulmonary regulatory mechanisms to generate predicted patient information, the predicted patient information comprising a serum pH level determined by the acid-base model based on a HCO2 concentration and a CO2 concentration, wherein:
the HCO2 concentration is determined based, at least in part, on a renal filtration rate of HCO2 model parameter, and
the CO2 concentration is determined based, at least in part, on a removal of CO2 through respiratory ventilation model parameter,
accessing the at least one treatment recommendation determined via the acid-base model;
diagnosing that the patient has the acid-base disorder; and
administering a treatment to the patient determined to correspond with the at least one treatment recommendation to treat the acid-base disorder, wherein the acid-base disorder is metabolic acidosis and the patient is treated with at least one of HCO2 therapy or acid-binder therapy.