US 12,230,397 B2
Assessment of endothelial cells and corneas at risk from ophthalmological images
David L. Wilson, Cleveland Heights, OH (US); Hao Wu, Cleveland Heights, OH (US); Naomi Joseph, Cleveland, OH (US); Chaitanya Kolluru, Cleveland Heights, OH (US); Beth Benetz, Cleveland, OH (US); and Jonathan Lass, Cleveland, OH (US)
Assigned to Case Western Reserve University, Cleveland, OH (US)
Filed by Case Western Reserve University, Cleveland, OH (US)
Filed on Jun. 22, 2020, as Appl. No. 16/908,059.
Claims priority of provisional application 62/889,750, filed on Aug. 21, 2019.
Prior Publication US 2021/0052157 A1, Feb. 25, 2021
Int. Cl. G16H 50/20 (2018.01); A61B 3/00 (2006.01); A61B 5/00 (2006.01); G06N 3/02 (2006.01); G06N 7/01 (2023.01); G06N 20/10 (2019.01); G06N 20/20 (2019.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01)
CPC G16H 50/20 (2018.01) [A61B 3/0025 (2013.01); A61B 5/4848 (2013.01); A61B 5/7264 (2013.01); G06N 3/02 (2013.01); G06N 7/01 (2023.01); G06N 20/10 (2019.01); G06N 20/20 (2019.01); G06T 7/0012 (2013.01); G06T 7/11 (2017.01); G06T 2207/10056 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30024 (2013.01); G06T 2207/30041 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising:
accessing an optical microscopy image comprising a set of corneal endothelial cells of a patient of a keratoplasty;
segmenting, based at least in part on a first model, a plurality of corneal endothelial cells of the set of corneal endothelial cells;
calculating one or more features from the segmented plurality of corneal endothelial cells, wherein calculating the one or more features includes calculating bright pigments, dark nuclei, and a thickness of dark gaps between cells of the segmented plurality of corneal endothelial cells; and
generating, via a second model using the one or more features, a prognosis associated with the keratoplasty at a time following the keratoplasty.