US 12,228,723 B2
Point-of-care-computational microscopy based-systems and methods
Rodger Michael Moore, Seattle, WA (US); Cordero Derrell Core, Birmingham, AL (US); Jaron Nathaniel Nix, Seattle, WA (US); Thomas Karl, Seattle, WA (US); Samatha Hastings, Renton, WA (US); and Samir Yhann, Seattle, WA (US)
Assigned to Pathware Inc., Golden, CO (US)
Filed by Pathware Inc., Golden, CO (US)
Filed on Feb. 6, 2024, as Appl. No. 18/434,304.
Application 18/434,304 is a continuation of application No. 17/735,351, filed on May 3, 2022, granted, now 11,927,738.
Application 17/735,351 is a continuation of application No. 17/415,227, granted, now 11,347,046, issued on May 31, 2022, previously published as PCT/US2019/066842, filed on Dec. 17, 2019.
Claims priority of provisional application 62/935,599, filed on Nov. 14, 2019.
Claims priority of provisional application 62/781,271, filed on Dec. 18, 2018.
Prior Publication US 2024/0248294 A1, Jul. 25, 2024
Int. Cl. G02B 21/36 (2006.01); G02B 21/06 (2006.01); G06V 20/69 (2022.01)
CPC G02B 21/367 (2013.01) [G02B 21/06 (2013.01); G06V 20/693 (2022.01); G06V 20/698 (2022.01)] 20 Claims
OG exemplary drawing
 
1. A point-of-care computational microscopy system, comprising:
an illumination source configured to illuminate an unstained biological specimen at one or more wavelengths;
a diffuser positioned to receive light from the illuminated unstained biological specimen;
one or more sensors configured to capture a sequence of images of the unstained biological specimen based on the diffused light; and
a hardware processor operatively coupled to the one or more sensors, the hardware processor being configured to:
cause the illumination source to illuminate the unstained biological specimen;
cause the one or more sensors to receive the diffused light from the illuminated unstained biological specimen and generate the sequence of images;
process the sequence of images captured by the one or more sensors;
generate a high-resolution image of the unstained biological specimen from the sequence of images; and
output, to a display, the high-resolution image for a point-of-care classification of the unstained biological specimen.