US 12,228,577 B2
Operating a mass spectrometer utilizing mass spectral database search
Derek J. Bailey, San Jose, CA (US)
Assigned to Thermo Finnigan LLC, San Jose, CA (US)
Filed by Thermo Finnigan LLC, San Jose, CA (US)
Filed on Dec. 14, 2023, as Appl. No. 18/540,423.
Application 18/540,423 is a continuation of application No. 16/426,929, filed on May 30, 2019, granted, now 11,879,897.
Prior Publication US 2024/0230661 A1, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/68 (2006.01); H01J 49/00 (2006.01); H01J 49/04 (2006.01); H01J 49/42 (2006.01)
CPC G01N 33/6848 (2013.01) [H01J 49/0036 (2013.01); H01J 49/0409 (2013.01); H01J 49/4295 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
a memory storing instructions; and
a processor communicatively coupled to the memory and configured to execute the instructions to:
execute, during an introduction period in which peptide ions are introduced into a mass spectrometer, a search of a database including information related to mass spectrums of candidate peptides for a match to a product ion spectrum produced by the mass spectrometer during the introduction period;
while executing the search of the database, monitor an elapsed search time and compare the elapsed search time with a maximum search time value that is shorter than the introduction period;
upon identification of a matching candidate peptide prior to the elapsed search time reaching the maximum search time value, cause the mass spectrometer to perform an action based on the identification;
upon the elapsed search time reaching the maximum search time value prior to an identification of a matching candidate peptide, terminate the search.