US 12,228,568 B2
Redox-labile fluorescent probes and their surface immobilization methods for the detection of metabolites
Wei Wei, Seattle, WA (US); Min Xue, Chino Hills, CA (US); Zhonghan Li, Portland, OR (US); and Hanjun Cheng, Seattle, WA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/258,427
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Jul. 8, 2019, PCT No. PCT/US2019/040872
§ 371(c)(1), (2) Date Jan. 6, 2021,
PCT Pub. No. WO2020/014153, PCT Pub. Date Jan. 16, 2020.
Claims priority of provisional application 62/695,699, filed on Jul. 9, 2018.
Prior Publication US 2021/0278401 A1, Sep. 9, 2021
Int. Cl. G01N 33/543 (2006.01); B01L 3/00 (2006.01); C09B 62/78 (2006.01); C09K 11/07 (2006.01); C12Q 1/26 (2006.01); C12Q 1/32 (2006.01)
CPC G01N 33/54353 (2013.01) [B01L 3/502761 (2013.01); C09B 62/78 (2013.01); C09K 11/07 (2013.01); C12Q 1/26 (2013.01); C12Q 1/32 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0893 (2013.01); B01L 2300/123 (2013.01); C09K 2211/1018 (2013.01)] 23 Claims
 
1. A compound, which has a redox-active resazurin moiety, wherein said compound is selected from the group consisting of

OG Complex Work Unit Chemistry
wherein n is 2 to 24;

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
wherein j and k are independently 2-46; and

OG Complex Work Unit Chemistry