US 12,228,495 B2
Flow nanoparticle measurement device and method of determining nanoparticle using the same
Su Yeon Oh, Gyeonggi-do (KR); Young Hoon Kim, Gyeonggi-do (KR); Seung Pil Han, Jeollabuk-do (KR); and Jun Hee Sung, Incheon (KR)
Assigned to DONGWOO FINE-CHEM CO., LTD., Jeollabuk-Do (KR)
Filed by DONGWOO FINE-CHEM CO., LTD., Jeollabuk-do (KR)
Filed on Oct. 20, 2021, as Appl. No. 17/506,090.
Claims priority of application No. 10-2020-0136344 (KR), filed on Oct. 20, 2020; and application No. 10-2021-0063592 (KR), filed on May 17, 2021.
Prior Publication US 2022/0120665 A1, Apr. 21, 2022
Int. Cl. G01N 15/14 (2024.01); G01N 15/1434 (2024.01); G01N 21/39 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01)
CPC G01N 15/1436 (2013.01) [G01N 15/1425 (2013.01); G01N 21/39 (2013.01); G01N 2015/0038 (2013.01); G01N 2015/1029 (2024.01)] 25 Claims
OG exemplary drawing
 
1. A device for measuring a nanoparticle having a flow, the device comprising:
a flow cell in which a liquid sample including the nanoparticle flows, a first laser beam being irradiated to the flow cell;
a laser generator configured to generate the first laser beam; and
a flow controller configured to control a flow of the liquid sample in the flow cell,
wherein the flow controller is configured to repeat the flow state and the flow stop state at a first period, and the laser generator repeatedly irradiates the first laser beam to the main flow portion at a second period corresponding to the first period,
wherein the flow cell includes a main flow portion configured to define a flow space in which the liquid sample flows, and configured so that the first laser beam is irradiated to the flow space,
wherein the flow controller is configured to alternately repeat a flow state and a flow stop state of the liquid sample,
wherein the flow state is a state in which the liquid sample flows through the main flow portion,
wherein the flow stop state is a state in which the flow of the liquid sample in the main flow portion is stopped,
wherein when the first laser beam is irradiated to the main flow portion, a plasma is generated in the main flow portion,
wherein the flow nanoparticle measurement device further comprise a detector configured to detect the plasma,
wherein the detector includes at least one of a shock wave detector detecting a shock wave of the plasma and a scintillation detector detecting a scintillation of the plasma.