US 12,227,805 B2
Genetic test for liver copper accumulation in dogs
Alan James Martin, Leicestershire (GB); Paul Glyn Jones, Leicestershire (GB); Adrian Watson, Aimargues (FR); Jan Rothuizen, Utrecht (NL); Hille Fieten, Utrecht (NL); and Pieter Antonius Jozef Leegwater, Utrecht (NL)
Assigned to MARS, INCORPORATED, McLean, VA (US)
Filed by MARS, INCORPORATED, McLean, VA (US)
Filed on Jun. 28, 2021, as Appl. No. 17/360,692.
Application 17/360,692 is a division of application No. 16/181,516, filed on Nov. 6, 2018, abandoned.
Application 16/181,516 is a division of application No. 14/363,751, granted, now 10,150,997, issued on Dec. 11, 2018, previously published as PCT/GB2012/053038, filed on Dec. 6, 2012.
Claims priority of application No. 1120989 (GB), filed on Dec. 6, 2011.
Prior Publication US 2022/0389506 A1, Dec. 8, 2022
Int. Cl. C12Q 1/68 (2018.01); A01K 67/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/6883 (2018.01); G16B 20/00 (2019.01); G16B 20/10 (2019.01); G16B 20/20 (2019.01); G16B 20/40 (2019.01)
CPC C12Q 1/6883 (2013.01) [A01K 67/02 (2013.01); G16B 20/00 (2019.02); G16B 20/10 (2019.02); G16B 20/20 (2019.02); G16B 20/40 (2019.02); C12Q 2600/124 (2013.01); C12Q 2600/156 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method of treating or breeding a dog, comprising:
(a) genotyping a biological sample obtained from the dog to determine in a genome of the dog presence or absence of a polymorphism of Chr22_3167534 (position 101 of SEQ ID NO: 144; and
(b) administering to the dog a low copper food stuff or a therapeutic amount of a copper chelator when the polymorphism is present; or
breeding the dog when the polymorphism is absent.