	US 12,227,745 B2
	Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
Marcin Tomasz Kortylewski, Monrovia, CA (US); Piotr Marek Swiderski, San Dimas, CA (US); Guido Marcucci, Azusa, CA (US); Bin Zhang, Duarte, CA (US); and Ya-Huei Kuo, Duarte, CA (US)
Assigned to City of Hope, Duarte, CA (US)
Filed by City of Hope, Duarte, CA (US)
Filed on Feb. 8, 2023, as Appl. No. 18/166,204.
Application 18/166,204 is a continuation of application No. 17/010,259, filed on Sep. 2, 2020, granted, now 11,591,596.
Application 17/010,259 is a continuation of application No. 15/768,405, granted, now 10,801,026, issued on Oct. 13, 2020, previously published as PCT/US2016/057143, filed on Oct. 14, 2016.
Claims priority of provisional application 62/242,189, filed on Oct. 15, 2015.
Prior Publication US 2023/0340479 A1, Oct. 26, 2023
Int. Cl. C07H 21/02 (2006.01); A61K 31/506 (2006.01); A61K 31/7004 (2006.01); A61K 31/704 (2006.01); A61K 31/7125 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61P 35/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01)

CPC C12N 15/113 (2013.01) [A61K 31/506 (2013.01); A61K 31/7004 (2013.01); A61K 31/704 (2013.01); A61K 31/7125 (2013.01); A61K 45/06 (2013.01); A61K 47/549 (2017.08); A61P 35/02 (2018.01); C12N 15/111 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/17 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3519 (2013.01)]

20 Claims

1. A compound comprising a phosphorothioated CpG oligodeoxynucleotide (CpG-ODN) conjugated to a nucleic acid sequence as set forth in SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, or SEQ ID NO:21.