US 12,227,624 B2
Molecular DNA strand-displacement controllers for directing material expansion
Angelo Cangialosi, Baltimore, MD (US); ChangKyu Yoon, Timonium, MD (US); Joshua Fern, Baltimore, MD (US); Thao D. Nguyen, Baltimore, MD (US); David H. Gracias, Baltimore, MD (US); and Rebecca Schulman, Baltimore, MD (US)
Assigned to THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
Appl. No. 16/964,467
Filed by THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
PCT Filed Jan. 22, 2019, PCT No. PCT/US2019/014439
§ 371(c)(1), (2) Date Jul. 23, 2020,
PCT Pub. No. WO2019/156801, PCT Pub. Date Aug. 15, 2019.
Claims priority of provisional application 62/620,669, filed on Jan. 23, 2018.
Prior Publication US 2021/0047478 A1, Feb. 18, 2021
Int. Cl. C12Q 1/6806 (2018.01); C08J 3/075 (2006.01)
CPC C08J 3/075 (2013.01) [C12Q 1/6806 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method of unlocking a locked gel comprising the steps of:
providing a locked gel comprising a polymer comprising a nucleic acid cross link and a nucleic acid lock in a locked conformation preventing the locked gel from reacting with other nucleic acid sequences;
adding a nucleic acid key that binds to the nucleic acid lock of the locked gel and further comprising a helper that binds to the nucleic acid lock that is bound to the nucleic acid key that allows the nucleic acid key to react with further nucleic acid sequences; and
changing the nucleic acid lock into an unlocked conformation, wherein the gel can react with other nucleic acid sequences.