US 12,227,598 B2
Glycophospholipid polymeric network and use thereof
Alok Kumar Awasthi, Pittsford, NY (US); James Anthony DiBella, Jr., Penfield, NY (US); Mark R. Mis, Rush, NY (US); Alai Musleh, Rochester, NY (US); and George L. Grobe, III, Ontario, NY (US)
Assigned to BAUSCH & LOMB INCORPORATED, Rochester, NY (US)
Filed by Bausch & Lomb Incorporated, Rochester, NY (US)
Filed on Apr. 26, 2023, as Appl. No. 18/139,434.
Application 18/139,434 is a division of application No. 16/815,630, filed on Mar. 11, 2020, granted, now 11,673,974.
Claims priority of provisional application 62/839,918, filed on Apr. 29, 2019.
Prior Publication US 2023/0257485 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C08B 37/08 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/685 (2006.01); A61K 31/728 (2006.01); A61L 26/00 (2006.01); A61L 27/34 (2006.01); G02B 1/18 (2015.01)
CPC C08B 37/0072 (2013.01) [A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/06 (2013.01); A61K 31/685 (2013.01); A61K 31/728 (2013.01); A61L 26/0023 (2013.01); A61L 27/34 (2013.01); G02B 1/18 (2015.01)] 20 Claims
 
1. A biomedical device having a coating on a surface thereof, the coating comprising a crosslinked glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans having one or more reactive functionality groups, one or more phospholipids having one or more reactive functionality groups and one or more first crosslinking agents, wherein the one or more first crosslinking agents comprise a bi- or polyfunctional crosslinking agent comprising two or more functional groups that are complementary to the one or more reactive functionality groups of the one or more glycosaminoglycans and the one or more phospholipids; wherein one of the two or more functional groups of the bi- or polyfunctional crosslinking agent is an epoxide functional group and a bond between the epoxide functional group of the bi- or polyfunctional crosslinking agent and at least one of the one or more reactive functionality groups of the one or more glycosaminoglycans is an ether bond.