US 12,227,589 B2
Epcam antibody and Epcam-CAR-T cells
Lijun Wu, Berkeley, CA (US); and Vita Golubovskaya, Pinole, CA (US)
Assigned to Forevertek Biotechnology Co., Ltd, Changsha (CN); and ProMab Biotechnologies, Inc., Richmond, CA (US)
Filed by ProMab Biotechnologies, Inc., Richmond, CA (US); and Forevertek Biotechnology Co., Ltd, Changsha (CN)
Filed on Jul. 21, 2021, as Appl. No. 17/381,537.
Application 17/381,537 is a continuation of application No. PCT/US2020/014999, filed on Jan. 24, 2020.
Claims priority of provisional application 62/796,975, filed on Jan. 25, 2019.
Prior Publication US 2021/0347909 A1, Nov. 11, 2021
Int. Cl. C07K 16/30 (2006.01); A61K 39/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 16/30 (2013.01) [A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464466 (2023.05); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 16/28 (2013.01); C12N 5/0636 (2013.01); A61K 2239/31 (2023.05); A61K 2239/50 (2023.05); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01)] 10 Claims
 
1. A humanized anti-human EpCAM antibody comprising VH having the amino acid of SEQ ID NO: 2 and VL having the amino acid of SEQ ID NO: 4.