1. A monoclonal antibody or a fragment thereof that recognizes and binds specifically to endothelin receptor type A or its extracellular domain as an antigen wherein the monoclonal antibody or fragment thereof comprises a heavy chain variable region comprising a CDR1 of SEQ ID NO: 38 and a CDR2 of SEQ ID NO: 39 and a light chain variable region comprising a CDR1 of SEQ ID NO: 40, a CDR2 of SEQ ID NO: 41, and a CDR3 of SEQ ID NO: 42 and wherein the CDR3 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 43 or a mutation selected from the group consisting of: a substitution of the amino acid at position 4 in the sequence of SEQ ID NO: 43 to proline (P), a substitution of the amino acid at position 7 in the sequence of SEQ ID NO: 43 to leucine (L), a substitution of the amino acid at position 9 in the sequence of SEQ ID NO: 43 to valine (V), a substitution of the amino acid at position 10 in the sequence of SEQ ID NO: 43 to isoleucine (I) or histidine (H), a substitution of the amino acid at position 11 in the sequence of SEQ ID NO: 43 to phenylalanine (F) or glutamine (Q), a substitution of the amino acid at position 12 in the sequence of SEQ ID NO: 43 to glutamate (E), a substitution of the amino acid at position 13 in the sequence of SEQ ID NO: 43 to asparagine (N) or cysteine (C) or a substitution of the amino acid at position 14 in the sequence of SEQ ID NO: 43 to leucine (L).