	US 12,227,552 B2
	Cell signaling complexes and uses thereof
Curtis Daniel Hodge, Pinole, CA (US); Zachary Ibrahim Imam, Concord, CA (US); and Luke Garland Haines, Pleasant Hill, CA (US)
Assigned to Nanotein Technologies, Inc., Berkeley, CA (US)
Filed by Nanotein Technologies, Inc., Berkeley, CA (US)
Filed on May 31, 2024, as Appl. No. 18/731,180.
Claims priority of provisional application 63/511,968, filed on Jul. 5, 2023.
Prior Publication US 2025/0011383 A1, Jan. 9, 2025
Int. Cl. C07K 14/54 (2006.01); C07K 14/55 (2006.01); C12N 5/0783 (2010.01)

CPC C07K 14/5443 (2013.01) [C07K 14/5418 (2013.01); C07K 14/55 (2013.01); C12N 5/0636 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01)]

27 Claims

1. A chimeric cytokine complex, comprising:

a protein cage polypeptide, wherein the protein cage polypeptide comprises polypeptides that self-assemble into a tetrahedral pyramid structure;

a plurality of engineered Fc antibody domains non-covalently bound to the protein cage polypeptide; and

one or more cytokines covalently linked to each of the plurality of engineered Fc antibody domains.