US 12,227,545 B2
Acinetobacter baumannii immunogenic protein and composition and application thereof
Hengliang Wang, Beijing (CN); Li Zhu, Beijing (CN); Chao Pan, Beijing (CN); Zhicheng Liu, Beijing (CN); Xin Li, Beijing (CN); Jun Wu, Beijing (CN); Peng Sun, Beijing (CN); Ming Zeng, Beijing (CN); Bin Wang, Beijing (CN); Xiankai Liu, Beijing (CN); Dongshu Wang, Beijing (CN); and Erling Feng, Beijing (CN)
Assigned to CHENGDU OLYMVAX BIOPHARMACEUTICALS INC., Chengdu (CN)
Appl. No. 17/058,527
Filed by CHENGDU OLYMVAX BIOPHARMACEUTICALS INC., Chengdu (CN)
PCT Filed May 23, 2019, PCT No. PCT/CN2019/088074
§ 371(c)(1), (2) Date Nov. 24, 2020,
PCT Pub. No. WO2019/223749, PCT Pub. Date Nov. 28, 2019.
Claims priority of application No. 201810510029.2 (CN), filed on May 24, 2018.
Prior Publication US 2021/0214400 A1, Jul. 15, 2021
Int. Cl. A61K 39/104 (2006.01); A61K 39/39 (2006.01); A61P 31/04 (2006.01); C07K 14/21 (2006.01); C07K 16/12 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/212 (2013.01) [A61K 39/1045 (2013.01); A61K 39/39 (2013.01); A61P 31/04 (2018.01); C07K 16/1218 (2023.08); A61K 2039/55544 (2013.01); C07K 2319/55 (2013.01)] 3 Claims
 
1. A method for protecting animals or humans from infection of Acinetobacter baumannii or a method for preventing and/or treating with diseases caused by Acinetobacter baumannii, which comprises the following steps:
immunizing a non-human animal or a human with a biomaterial to achieve resistance to Acinetobacter baumannii infection, wherein the biomaterial is one of the following:
1) a protein consisting of 39 amino acids in the N-terminal α-helix part of the Ata protein transport functional domain of Acinetobacter baumannii;
2) a protein composition consisting of 39 amino acids in the N-terminal α-helix part of the Ata protein transport functional domain of Acinetobacter baumannii and an adjuvant protein or a protein fragment with adjuvant function;
3) a fusion protein consisting of 39 amino acids in the N-terminal α-helix part of the Ata protein transport functional domain of Acinetobacter baumannii and an adjuvant protein or a protein fragment with adjuvant function;
wherein the amino acid sequence of said 39 amino acids in the N-terminal α-helix part of the Ata protein transport functional domain of Acinetobacter baumannii is shown as the amino acid residues 127-165 of SEQ ID NO: 2,
wherein the fusion protein is any one of the following a)-c):
a) the amino acid sequence consisting of the amino acid residues shown as SEQ ID NO: 2 in the sequence listing;
b) a fusion protein obtained by attaching a tag to the N-terminal and/or C-terminal of the protein defined in a); and
c) a protein whose amino acid sequence consists of the amino acid residues 20-165 of SEQ ID NO: 2 in the sequence listing.