US 12,227,543 B2
Ancestral virus sequences and uses thereof
Luk H. Vandenberghe, Weston, MA (US); and Eric Zinn, Lynn, MA (US)
Assigned to Massachusetts Eye and Ear Infirmary, Boston, MA (US); and The Schepens Eye Research Institute, Inc., Boston, MA (US)
Filed by Massachusetts Eye and Ear Infirmary, Boston, MA (US); and The Schepens Eye Research Institute, Inc., Boston, MA (US)
Filed on Aug. 10, 2020, as Appl. No. 16/989,454.
Application 16/989,454 is a continuation of application No. 15/748,738, granted, now 10,738,087, previously published as PCT/US2016/044819, filed on Jul. 29, 2016.
Claims priority of provisional application 62/203,002, filed on Aug. 10, 2015.
Claims priority of provisional application 62/199,059, filed on Jul. 30, 2015.
Prior Publication US 2021/0017235 A1, Jan. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/00 (2006.01); C07K 14/005 (2006.01); C07K 14/015 (2006.01); C12N 15/86 (2006.01); C12Q 1/70 (2006.01)
CPC C07K 14/005 (2013.01) [C12N 15/86 (2013.01); C12Q 1/701 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01)] 25 Claims
 
1. An adeno-associated virus (AAV) capsid polypeptide having at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 58.