US 12,227,542 B2
Method for producing peptide compound, protective group-forming reagent, and condensed polycyclic compound
Yosuke Yamamoto, Kanagawa (JP); and Makoto Takahashi, Kanagawa (JP)
Assigned to FUJIFILM CORPORATION, Tokyo (JP)
Filed by FUJIFILM CORPORATION, Tokyo (JP)
Filed on Dec. 21, 2021, as Appl. No. 17/558,542.
Application 17/558,542 is a continuation of application No. PCT/JP2020/024232, filed on Jun. 19, 2020.
Claims priority of application No. 2019-122492 (JP), filed on Jun. 28, 2019; and application No. 2019-221545 (JP), filed on Dec. 6, 2019.
Prior Publication US 2022/0112234 A1, Apr. 14, 2022
Int. Cl. C07K 1/06 (2006.01)
CPC C07K 1/065 (2013.01) 7 Claims
 
1. A method for producing a peptide compound, comprising:
a step of using a compound represented by Formula (1),

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in Formula (1),
Y1 represents —SH, Br, Cl, —OH, —NH2, —NHEt, where Et represents an ethyl group, or —NHFmoc, where Fmoc represents a 9-fluorenylmethoxycarbonyl group,
Y2 represents —O—, —S—, —CH═CH—, —C(CH3)═C(CH3)—, —CH2—CH2—, —C(CH3)2—,

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R1, R2, R5, R7, and R8 each represent a hydrogen atom,
R3 represents a hydrogen atom,

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 —OC22H45, or —OC12H24OC22H45,
R4 represents a hydrogen atom or —NH2,
R6 represents a hydrogen atom,

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 —OC22H45, or —OC12H24OC22H45,
provided that at least one of the following (i), (ii), or (iii) is satisfied:
(i) Y2 represents

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(ii) R3 represents

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 —OC22H45, or —OC12H24OC22H45; or
(iii) R6 represents

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 —OC22H45, or —OC12H24OC22H45.