US 12,227,516 B1
Selective COX-2 inhibition of 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-n-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide as anti-inflammatory agents
Katharigatta N. Venugopala, Al-Ahsa (SA); Pran Kishore Deb, Ranchi (IN); Raghu Prasad Mailavaram, Dhule (IN); Nizar A. Al-Shar'i, Irbid (JO); Swastika Ganguly, Ranchi (IN); Bapi Gorain, Ranchi (IN); Annie Lee Pei Wen, Kuala Lumpur (MY); and Goh Hui Shan, Kuala Lumpur (MY)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Sep. 21, 2023, as Appl. No. 18/371,095.
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 495/04 (2006.01)
CPC C07D 495/04 (2013.01) 4 Claims
 
1. A compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R is —NHCOPhenyl wherein the phenyl in the —NHCOPhenyl is substituted with a fluorine.