	US 12,227,514 B2
	Crystal forms of thiophene derivatives
Donglei Zhang, Tianjin (CN); Liyu Wang, Tianjin (CN); and Yukun Chang, Tianjin (CN)
Assigned to TIANJIN HEMAY PHARMACEUTICAL CO., LTD., Tianjin (CN)
Appl. No. 17/052,128
Filed by TIANJIN HEMAY PHARMACEUTICAL CO., LTD., Tianjin (CN)
PCT Filed Apr. 30, 2019, PCT No. PCT/CN2019/085327 § 371(c)(1), (2) Date Oct. 30, 2020, PCT Pub. No. WO2019/210864, PCT Pub. Date Nov. 7, 2019.
Claims priority of application No. 201810407741.X (CN), filed on May 2, 2018.
Prior Publication US 2021/0139498 A1, May 13, 2021
Int. Cl. C07D 495/04 (2006.01)

CPC C07D 495/04 (2013.01) [C07B 2200/13 (2013.01)]

35 Claims

1. Crystal form I of compound (S)—N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide, having characteristic peaks at diffraction angles 2θ of about 5.3°, 9.2°, 16.1°, 17.7°, 20.6°, 26.2° and 26.7° in an X-ray powder diffraction (XRPD) pattern.