US 12,227,500 B2
Substituted pyrrolo[2,3-b]pyridines for suppressing toxic endoplasmic reticulum stress
Brent R. Stockwell, New York, NY (US); Hynek Wichterle, New York, NY (US); Pieter Bos, New York, NY (US); Arie Zask, New York, NY (US); Sebastian Thams, Stockholm (SE); and Emily Rhodes Lowry, Brooklyn, NY (US)
Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US)
Filed by THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US)
Filed on Sep. 1, 2020, as Appl. No. 17/009,450.
Application 17/009,450 is a continuation of application No. PCT/US2019/020362, filed on Mar. 1, 2019.
Claims priority of provisional application 62/637,242, filed on Mar. 1, 2018.
Prior Publication US 2021/0040091 A1, Feb. 11, 2021
Int. Cl. A61K 31/437 (2006.01); C07D 471/04 (2006.01)
CPC C07D 471/04 (2013.01) 87 Claims
 
1. A compound selected from the group consisting of:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.
 
34. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound selected from the group consisting of:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.