US 12,227,486 B1
Systems and methods for the production of levulinic acid, furfural, and formic acid
Stephen W. Fitzpatrick, Framingham, MA (US)
Assigned to Biofine Technology, LLC, Brookline, MA (US)
Filed by Biofine Technology LLC, Brookline, MA (US)
Filed on Jul. 29, 2024, as Appl. No. 18/787,536.
Int. Cl. C07D 307/50 (2006.01); C07C 51/00 (2006.01)
CPC C07D 307/50 (2013.01) [C07C 51/00 (2013.01)] 12 Claims
 
1. A method, comprising:
supplying a reactant mixture comprising a feedstock comprising cellulose and hemicellulose, and 2 wt. % to 10 wt. % of a mineral acid catalyst in a reactor;
providing steam to the reactant mixture;
condensing a first portion of the steam to heat the reactant mixture;
converting at least a portion of the cellulose to levulinic acid and formic acid and at least a portion of the hemicellulose into furfural; and
removing at least a portion of the furfural from the reactor using a second portion of the steam different from the first portion of the steam by steam stripping;
wherein:
the feedstock comprises a member selected from the group consisting of lignocellulose, wood, wood pulp, forestry trimmings, paper, corrugated cardboard, sawdust, paper pulp, agricultural residues, food processing waste, and kelp;
a liquid phase residence time in the reactor is 30 minutes to 60 minutes;
an amount of steam provided to the reactant mixture corresponds to an amount of steam calculated to heat the reactant mixture to a temperature of 190° C. to 205° C. as well as an additional amount of steam calculated to reduce an amount of furfural in the reactant mixture below 0.35 wt. %;
a steam stripping rate is selected to provide a stripping factor of from 0.25 to 1.75;
the reactor comprises a back-pressure control valve;
removing at least a portion of the furfural using a second portion of the steam forms a vapor stream comprising steam and furfural;
the vapor stream passes through the back-pressure control valve; and
at a fixed steam supply rate, a flow rate of the vapor stream through the back-pressure control valve controls a pressure of the reactor and a temperature of the reactor.