US 12,227,472 B2
Series of skin-whitening (lightening) compounds
Sandip K. Nandy, Olympia, WA (US); Jiyun Liu, Bothell, WA (US); Alexandre Mikhailovitch Nesterov, Olympia, WA (US); Carmen Hertel, Tacoma, WA (US); and Abeysinghe Arrachchigae Papmapiya, Olympia, WA (US)
Assigned to Unigen, Inc., Tacoma, WA (US)
Filed by Unigen, Inc., Tacoma, WA (US)
Filed on Aug. 28, 2023, as Appl. No. 18/238,905.
Application 13/722,394 is a division of application No. 12/506,497, filed on Jul. 21, 2009, granted, now 8,362,305, issued on Jan. 29, 2013.
Application 18/238,905 is a continuation of application No. 17/194,617, filed on Mar. 8, 2021, granted, now 11,739,040.
Application 17/194,617 is a continuation of application No. 16/380,769, filed on Apr. 10, 2019, granted, now 10,941,098, issued on Mar. 9, 2021.
Application 16/380,769 is a continuation of application No. 15/620,395, filed on Jun. 12, 2017, granted, now 10,259,764, issued on Apr. 16, 2019.
Application 15/620,395 is a continuation of application No. 14/750,873, filed on Jun. 25, 2015, granted, now 9,682,910, issued on Jun. 20, 2017.
Application 14/750,873 is a continuation of application No. 14/154,013, filed on Jan. 13, 2014, granted, now 9,096,507, issued on Aug. 4, 2015.
Application 14/154,013 is a continuation of application No. 13/722,394, filed on Dec. 20, 2012, granted, now 8,658,838, issued on Feb. 25, 2014.
Claims priority of provisional application 61/082,422, filed on Jul. 21, 2008.
Prior Publication US 2023/0399282 A1, Dec. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 43/295 (2006.01); A23B 7/154 (2006.01); A23L 3/3481 (2006.01); A61K 8/34 (2006.01); A61K 8/49 (2006.01); A61K 31/09 (2006.01); A61K 31/341 (2006.01); A61K 31/357 (2006.01); A61K 31/4406 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01); C07C 39/11 (2006.01); C07C 39/15 (2006.01); C07C 43/23 (2006.01); C07C 45/67 (2006.01); C07C 45/74 (2006.01); C07C 49/83 (2006.01); C07D 213/30 (2006.01); C07D 213/64 (2006.01); C07D 263/57 (2006.01); C07D 307/12 (2006.01); C07D 307/42 (2006.01); C07D 317/54 (2006.01)
CPC C07C 43/295 (2013.01) [A23B 7/154 (2013.01); A23L 3/3481 (2013.01); A61K 8/345 (2013.01); A61K 8/347 (2013.01); A61K 8/4926 (2013.01); A61K 8/4973 (2013.01); A61K 31/09 (2013.01); A61K 31/341 (2013.01); A61K 31/357 (2013.01); A61K 31/4406 (2013.01); A61Q 19/02 (2013.01); A61Q 19/08 (2013.01); C07C 39/11 (2013.01); C07C 39/15 (2013.01); C07C 43/23 (2013.01); C07C 45/673 (2013.01); C07C 45/74 (2013.01); C07C 49/83 (2013.01); C07D 213/30 (2013.01); C07D 213/64 (2013.01); C07D 263/57 (2013.01); C07D 307/12 (2013.01); C07D 307/42 (2013.01); C07D 317/54 (2013.01); A61K 2800/782 (2013.01)] 4 Claims
 
1. A composition comprising the compound of Formula V:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of H or C1-C10 alkyl;
Bn is a benzyl; and
R′ is 1 to 3 moieties (R′, R″, R′″) independently selected from the group consisting of a C1-C10 alkyl group, a C1-C10 alkoxy group or a hydroxyl group; and
a pharmaceutically or cosmetically acceptable carrier.