US 12,227,467 B2
Process for bio-1,3-butanediol purification from a fermentation broth
Mario Baldassarre, Novara (IT); Alberto Cesana, Novara (IT); and Fabrizio Bordes, Novara (IT)
Assigned to Versalis S.P.A., San Donato Milanese (IT)
Appl. No. 17/277,968
Filed by VERSALIS S.P.A., San Donato Milanese (IT)
PCT Filed Sep. 19, 2019, PCT No. PCT/EP2019/075123
§ 371(c)(1), (2) Date Mar. 19, 2021,
PCT Pub. No. WO2020/058381, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 102018000008820 (IT), filed on Sep. 21, 2018.
Prior Publication US 2021/0380512 A1, Dec. 9, 2021
Int. Cl. C07C 29/76 (2006.01); B01D 15/36 (2006.01); B01D 21/26 (2006.01); B01D 61/02 (2006.01); B01D 61/14 (2006.01); B01D 61/58 (2006.01); B01D 69/02 (2006.01); B01J 23/10 (2006.01); C07C 1/24 (2006.01); C07C 29/80 (2006.01); C07C 31/20 (2006.01); C08F 36/06 (2006.01); C12P 7/18 (2006.01)
CPC C07C 29/76 (2013.01) [B01D 15/362 (2013.01); B01D 15/363 (2013.01); B01D 21/262 (2013.01); B01D 61/027 (2013.01); B01D 61/147 (2013.01); B01D 61/58 (2013.01); B01D 69/02 (2013.01); B01J 23/10 (2013.01); C07C 1/24 (2013.01); C07C 29/80 (2013.01); C08F 36/06 (2013.01); C12P 7/18 (2013.01); B01D 2325/02834 (2022.08); B01D 2325/34 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A process for bio-1,3-butanediol purification from a fermentation broth, the process comprising the following steps:
(a) subjecting the fermentation broth to separation;
(b) subjecting the product obtained in step (a) to treatment with ion-exchange resins;
(c) subjecting the product obtained in step (b) to a first evaporation at a temperature ranging from 30° C. to 100° C. and/or at a pressure ranging from 5 mbar to 100 mbar;
(d) subjecting the product obtained in step (c) to a second evaporation; and
(e) subjecting the product obtained in step (d) to a third evaporation, thereby obtaining purified bio-1,3-butanediol.