US 12,226,957 B2
Systems and methods for producing a mixer
Trinh Vo, Frederick, MD (US); Huyun Chen, Peachtree City, GA (US); and Amardeep Singh Bhupender Bhalla, Montvale, NJ (US)
Assigned to Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed on Aug. 5, 2021, as Appl. No. 17/395,176.
Claims priority of provisional application 63/150,540, filed on Feb. 17, 2021.
Claims priority of provisional application 63/085,080, filed on Sep. 29, 2020.
Claims priority of provisional application 63/062,129, filed on Aug. 6, 2020.
Prior Publication US 2022/0040926 A1, Feb. 10, 2022
Int. Cl. B29C 64/386 (2017.01); B01F 27/90 (2022.01); B01F 35/512 (2022.01); B01F 35/53 (2022.01); B29C 64/00 (2017.01); B29C 64/10 (2017.01); B29C 64/30 (2017.01); B29L 31/08 (2006.01); B33Y 40/20 (2020.01); B33Y 50/00 (2015.01); B33Y 80/00 (2015.01); B01F 101/22 (2022.01)
CPC B29C 64/386 (2017.08) [B01F 27/90 (2022.01); B01F 35/512 (2022.01); B01F 35/5312 (2022.01); B29C 64/00 (2017.08); B29C 64/10 (2017.08); B29C 64/30 (2017.08); B33Y 40/20 (2020.01); B33Y 50/00 (2014.12); B33Y 80/00 (2014.12); B01F 2101/22 (2022.01); B29L 2031/08 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for producing a first mixer for mixing biopharmaceutical proteins into an aqueous formulation, the system comprising:
a first plurality of dimensions based on a respective plurality of dimensions of a second mixer;
a second plurality of dimensions independent of the respective plurality of dimensions of the second mixer, wherein the second plurality of dimensions is generated by a computational fluid dynamic technique simulating physical forces on an impeller and shear forces on the biopharmaceutical proteins in the aqueous formulation by the impeller over various rotational velocities, fluid densities, and temperatures, and wherein the second plurality of dimensions are calculated to prevent degradation of the biopharmaceutical proteins in the aqueous formulation;
a three-dimensional printer configured to receive the first plurality of dimensions and the second plurality of dimensions and produce the first mixer, wherein the first mixer has a plurality of dimensions based on a combination of the first plurality of dimensions and the second plurality of dimensions; and
a smoothing apparatus configured to smooth a surface of the first mixer, wherein smoothing the surface of the first mixer prevents degradation of the biopharmaceutical proteins in the aqueous formulation.