US 12,226,710 B2
Chromatographic separation of metals using DOTA-based chelators
Thomas Jacobus Maria Molenaar, Petten (NL); and Sander De Groot, Petten (NL)
Assigned to STICHTING NUCLEAR RESEARCH AND CONSULTANCY GROUP, Petten (NL)
Filed by NUCLEAR RESEARCH AND CONSULTANCY GROUP, Petten (NL)
Filed on Jun. 17, 2022, as Appl. No. 17/843,542.
Application 17/843,542 is a continuation of application No. PCT/EP2020/086847, filed on Dec. 17, 2020.
Claims priority of application No. 19218962 (EP), filed on Dec. 20, 2019; and application No. 20167932 (EP), filed on Apr. 3, 2020.
Prior Publication US 2022/0401856 A1, Dec. 22, 2022
Int. Cl. B01D 15/38 (2006.01); C07D 273/00 (2006.01); C07D 471/08 (2006.01); C22B 3/22 (2006.01); C22B 59/00 (2006.01); C22B 60/02 (2006.01)
CPC B01D 15/3828 (2013.01) [C07D 273/00 (2013.01); C07D 471/08 (2013.01); C22B 3/22 (2013.01); C22B 59/00 (2013.01); C22B 60/02 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A compound of general formula (I):

OG Complex Work Unit Chemistry
A is N or C substituted with one of H, halogen (Cl, Br, F), SO3H, C1-4 alkyl, aryl, hetaryl, C—O—C1-16 alkylamino,
Z and Z1 independently are N or C substituted with one of H, halogen (Cl, Br, F), SO3H, C1-4 alkyl, aryl, hetaryl, C—O—C1-16 alkylamino,
E=O, S or P;
R1 is independently substituted or unsubstituted C4-15alkylaryl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, or substituted or unsubstituted heteroaryl, wherein the substitution is by one or more moiety(ies) selected from a group consisting of imide, —C(O)(CH2)0-3CH3, C2-5carboxyl, —(CH2)1-3C(O)(CH2)0-3CH3, nitro, amino, thiol, succinimide, maleimide, aminooxyl, acetylene, N3, acetamino, azide, —C(O)O(CH2)1-3CH3, —OC(O)(CH2)0-3CH3, halogen, C1-5alkynyl, and NCS;
and a=0-5.