US 12,226,640 B2
Systems and methods for normalizing cardiac electrical conditions of measured hemodynamic variations for use in cardiac pacing device optimization processes
Cyrille Casset, Saint Selve (FR); Louis-Philippe Richer, Montreal (FR); Craig D. Markovitz, Leipzig (DE); and Jan Mangual-Soto, Rho (IT)
Assigned to Pacesetter, Inc., Sylmar, CA (US)
Filed by PACESETTER, INC., Sylmar, CA (US)
Filed on Sep. 11, 2017, as Appl. No. 15/701,209.
Prior Publication US 2019/0076660 A1, Mar. 14, 2019
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61B 5/349 (2021.01); A61N 1/362 (2006.01); A61N 1/365 (2006.01); A61N 1/368 (2006.01); A61N 1/37 (2006.01)
CPC A61N 1/36585 (2013.01) [A61B 5/349 (2021.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61N 1/3627 (2013.01); A61N 1/36842 (2017.08); A61N 1/36843 (2017.08); A61N 1/3706 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for optimizing pacing parameters of a cardiac pacing device implanted in a patient, the method comprising:
selecting a reference pacing parameter set and a variable pacing parameter, wherein the reference pacing parameter set comprises a value of the variable pacing parameter;
measuring a reference ECG associated with the cardiac pacing device configured with the reference pacing parameter set;
measuring a series of baseline ECGs, each baseline ECG of the series associated with the cardiac pacing device configured with the reference pacing parameter set having a different value of the variable pacing parameter;
determining a series of baseline correlation coefficients, each baseline correlation coefficient indicative of a correlation between a respective baseline ECG of the series and the reference ECG;
selecting a threshold correlation coefficient that corresponds to a degree of a match represented by one of the series of baseline correlation coefficients;
defining the threshold correlation coefficient as a criterion for classifying electrical equivalents to the reference ECG, wherein each baseline ECG associated with a baseline correlation coefficient greater than the threshold correlation coefficient is classified as electrically equivalent to the reference ECG;
identifying a plurality of candidate pacing parameter sets, wherein each of the plurality of candidate pacing parameter sets is classified as electrically equivalent to the reference ECG due to a correlation coefficient between i) an ECG measured with the cardiac pacing device configured with the candidate pacing parameter set and ii) the reference ECG being greater than the threshold correlation coefficient;
measuring a plurality of hemodynamic responses of the patient, each hemodynamic response associated with the cardiac pacing device configured with one of the identified candidate pacing parameter sets;
identifying an optimal hemodynamic response from the plurality of hemodynamic responses;
selecting a final candidate pacing parameter set corresponding to the optimal hemodynamic response; and
programming the cardiac pacing device using the final candidate pacing parameter set.