US 12,226,552 B2
Active agent depots formed in situ
Joram Slager, St. Louis Park, MN (US)
Assigned to Surmodics, Inc., Eden Prairie, MN (US)
Filed by Surmodics, Inc., Eden Prairie, MN (US)
Filed on Sep. 30, 2020, as Appl. No. 17/038,171.
Claims priority of provisional application 62/908,236, filed on Sep. 30, 2019.
Prior Publication US 2021/0093753 A1, Apr. 1, 2021
Int. Cl. A61L 31/04 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01)
CPC A61L 31/046 (2013.01) [A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/204 (2013.01); A61L 2300/252 (2013.01); A61L 2300/418 (2013.01); A61L 2300/602 (2013.01); A61L 2430/36 (2013.01)] 15 Claims
 
1. A method of forming an active agent releasing depot in situ comprising
contacting a layer of a composition with a vessel wall;
wherein the composition comprises
a first gradient layer comprising a first active agent;
a second gradient layer comprising the first active agent and a second active agent, wherein the first gradient layer is disposed over the second gradient layer; and
a third gradient layer comprising the first active agent and a third active agent, wherein the second gradient layer is disposed over the third gradient layer;
wherein the first gradient layer, the second gradient layer, and the third gradient layer all comprise a fibrin promoting vessel wall transfer agent;
wherein the composition has an increasing concentration gradient of the first active agent from the first gradient layer to the third gradient layer;
transferring the layer of the composition from a device surface to the vessel wall surface; and
forming an initial fibrin matrix around the composition.