CPC A61L 31/046 (2013.01) [A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/204 (2013.01); A61L 2300/252 (2013.01); A61L 2300/418 (2013.01); A61L 2300/602 (2013.01); A61L 2430/36 (2013.01)] | 15 Claims |
1. A method of forming an active agent releasing depot in situ comprising
contacting a layer of a composition with a vessel wall;
wherein the composition comprises
a first gradient layer comprising a first active agent;
a second gradient layer comprising the first active agent and a second active agent, wherein the first gradient layer is disposed over the second gradient layer; and
a third gradient layer comprising the first active agent and a third active agent, wherein the second gradient layer is disposed over the third gradient layer;
wherein the first gradient layer, the second gradient layer, and the third gradient layer all comprise a fibrin promoting vessel wall transfer agent;
wherein the composition has an increasing concentration gradient of the first active agent from the first gradient layer to the third gradient layer;
transferring the layer of the composition from a device surface to the vessel wall surface; and
forming an initial fibrin matrix around the composition.
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