US 12,226,550 B2
Method of manufacturing a bioimplant
Masaaki Mawatari, Saga (JP); Masatsugu Tsukamoto, Saga (JP); and Iwao Noda, Osaka (JP)
Assigned to SAGA UNIVERSITY, Saga (JP); and KYOCERA CORPORATION, Kyoto (JP)
Filed by SAGA UNIVERSITY, Saga (JP); and KYOCERA CORPORATION, Kyoto (JP)
Filed on Dec. 21, 2022, as Appl. No. 18/086,506.
Application 18/086,506 is a continuation of application No. 17/080,460, filed on Oct. 26, 2020, granted, now 11,577,006.
Application 17/080,460 is a continuation of application No. 15/405,156, filed on Jan. 12, 2017, granted, now 10,814,039.
Application 15/405,156 is a continuation in part of application No. 14/376,183, abandoned, previously published as PCT/JP2013/050661, filed on Jan. 16, 2013.
Claims priority of application No. 2012-022205 (JP), filed on Feb. 3, 2012.
Prior Publication US 2023/0121881 A1, Apr. 20, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/32 (2006.01); A61L 27/54 (2006.01)
CPC A61L 27/54 (2013.01) [A61L 27/32 (2013.01); A61L 2300/104 (2013.01); A61L 2300/404 (2013.01); A61L 2420/02 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method of manufacturing a bioimplant, comprising: providing a base material of the bioimplant;
forming a coating comprising a calcium phosphate-based material and a silver material on at least a part of a surface of the base material;
after forming the coating, heating the coating at a predetermined temperature under a predetermined pressure to form oxyapatite in the coating; and
immersing the coating in purified water to convert oxyapatite present in the coating to hydroxyapatite, wherein the immersing results in fine crystals of the hydroxyapatite being formed on a surface of the coating, wherein a size of the fine crystals of hydroxyapatite is in a range of 0.01 μm to 2.00 μm in length, thickness or width, and
wherein a temperature of the purified water is in a range of 60 to 100 degrees Celsius.