US 12,226,549 B2
Synergistically cooperative compositions useful for soft tissue augmentation, drug delivery and related fields
Assunta Borzacchiello, Naples (IT); Maurizio Pagliuca, Lugano (CH); Nicola Solimando, Lugano (CH); and Luigi Nicolais, Ercolano (IT)
Assigned to ALTERGON S.A., Lugano (CH)
Appl. No. 17/264,134
Filed by ALTERGON S.A., Lugano (CH)
PCT Filed Jul. 24, 2019, PCT No. PCT/EP2019/069892
§ 371(c)(1), (2) Date Jan. 28, 2021,
PCT Pub. No. WO2020/025415, PCT Pub. Date Feb. 6, 2020.
Claims priority of application No. 102018000007683 (IT), filed on Jul. 31, 2018.
Prior Publication US 2022/0118155 A1, Apr. 21, 2022
Int. Cl. A61L 27/26 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/407 (2006.01); A61K 31/421 (2006.01); A61K 31/4365 (2006.01); A61K 31/4706 (2006.01); A61K 31/496 (2006.01); A61K 31/5415 (2006.01); A61K 31/60 (2006.01); A61K 31/616 (2006.01); A61K 47/22 (2006.01); A61K 47/36 (2006.01); A61K 47/40 (2006.01)
CPC A61L 27/26 (2013.01) [A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/407 (2013.01); A61K 31/421 (2013.01); A61K 31/4365 (2013.01); A61K 31/4706 (2013.01); A61K 31/496 (2013.01); A61K 31/5415 (2013.01); A61K 31/60 (2013.01); A61K 31/616 (2013.01); A61K 47/22 (2013.01); A61K 47/36 (2013.01); A61K 47/40 (2013.01); A61L 2300/21 (2013.01); A61L 2300/216 (2013.01); A61L 2300/232 (2013.01); A61L 2300/236 (2013.01); A61L 2300/41 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A synergistically cooperative, aqueous solution comprising components in dissolved form:
(a) hyaluronic acid or a salt thereof at a weight concentration of 0.01 to 25%,
(b) a cyclodextrin at a weight concentration of 0.01 to 25%,
(c) one or more tocopherols or tocotrienols and mixtures thereof at a weight concentration of 0.0001 to 15%, by weight of the solution,
wherein said components (a), (b) and (c) are not engaged in formal chemical binding with each other, and
wherein the synergistically cooperative, aqueous solution with the components in dissolved form exhibits an increased dynamic modulus (G′) from said components (a), (b) and (c) over an added, dynamic modulus (G′) calculated from said components (a), (b) and (c).