	US 12,226,535 B2
	Microneedle adhesive patch based on hydrogel formulation
Hyung Joon Cha, Gyeongsangbuk-do (KR); Eun Young Jeon, Gyeongsangbuk-do (KR); Jung Ho Lee, Gyeonggi-do (KR); and Geun Bae Lim, Gyeongsangbuk-do (KR)
Assigned to POSTECH ACADEMY-INDUSTRY FOUNDATION, Pohang-si (KR)
Appl. No. 17/056,340
Filed by POSTECH ACADEMY-INDUSTRY FOUNDATION, Gyeongsangbuk-do (KR)
PCT Filed May 17, 2019, PCT No. PCT/KR2019/005952 § 371(c)(1), (2) Date Nov. 17, 2020, PCT Pub. No. WO2019/221559, PCT Pub. Date Nov. 21, 2019.
Claims priority of application No. 10-2018-0057040 (KR), filed on May 18, 2018.
Prior Publication US 2021/0275359 A1, Sep. 9, 2021
Int. Cl. A61L 15/32 (2006.01); A61F 13/00 (2024.01); A61F 13/02 (2024.01); A61L 15/28 (2006.01); A61L 15/58 (2006.01); A61L 15/60 (2006.01); A61M 37/00 (2006.01)

CPC A61L 15/32 (2013.01) [A61F 13/00063 (2013.01); A61F 13/023 (2013.01); A61L 15/28 (2013.01); A61L 15/58 (2013.01); A61L 15/60 (2013.01); A61M 37/0015 (2013.01); A61F 2013/00451 (2013.01)]

10 Claims

1. A microneedle patch comprising:

a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid; and

a second hydrogel layer containing silk fibroin,

wherein the mussel adhesive protein is crosslinked by covalent bonds, and

wherein the weight ratio of the hyaluronic acid to the mussel adhesive protein ranges from 2:8 to 3:7.