	US 12,226,531 B2
	Compositions and methods for improving nitrogen utilization in a ruminant
Thomas Haeussner, Eppertshausen (DE); Frank Fischer, Hofheim (DE); Georg Borchers, Bad Nauheim (DE); Ulrike Kottke, Linsengericht-Grossenhausen (DE); Christoph Kobler, Alzenau (DE); Cornelia Borgmann, Frankfurt (DE); and Karsten Portner, Frankfurt (DE)
Assigned to Evonik Operations GmbH, Essen (DE)
Appl. No. 16/651,062
Filed by Evonik Operations GmbH, Essen (DE)
PCT Filed Sep. 27, 2018, PCT No. PCT/EP2018/076234 § 371(c)(1), (2) Date Mar. 26, 2020, PCT Pub. No. WO2019/063678, PCT Pub. Date Apr. 4, 2019.
Claims priority of application No. 17193721 (EP), filed on Sep. 28, 2017.
Prior Publication US 2020/0222331 A1, Jul. 16, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/50 (2006.01); A61K 31/17 (2006.01)

CPC A61K 9/5015 (2013.01) [A61K 9/5063 (2013.01); A61K 31/17 (2013.01)]

5 Claims

1. A composition for feeding a ruminant, the composition consisting of:

i) a non-protein nitrogen compound, and

ii) a coating surrounding the non-protein nitrogen compound,

wherein said coating consists of two layers,

wherein a first layer consists of 60-85 wt. % of a saturated fat and 15-40 wt. % of a fatty acid based on a weight of the first layer,

wherein a second layer consists of 60 to 97 wt. % of the saturated fat and 3 to 40 wt. % of the fatty acid based on a weight of the second layer,

wherein each of the two layers have a different amount of the saturated fat and the fatty acid,

wherein the composition consists of 10 to 20 wt. % of the coating, based on a total weight of the composition,

wherein the non-protein nitrogen compound is urea,

wherein the saturated fat is hydrogenated palm oil,

wherein the fatty acid is stearic acid, and

wherein on feeding the composition to the ruminant the composition has a rumen protected urea fraction of 54.1-99.4% and a total digestible urea fraction of 60.2-97.8%.