US 12,226,527 B2
Gel formulations for local drug release
Thomas Lars Andresen, Vanløse (DK); Linda Maria Bruun, Fredriksberg (DK); Trine Bjørnbo Larsen, København N (DK); Rasmus Irming Jølck, Kgs. Lyngby (DK); and Anders Elias Hansen, Bunkeflostrand (SE)
Assigned to TECHNICAL UNIVERSITY OF DENMARK, KGS Lyngby (DK)
Filed by TECHNICAL UNIVERSITY OF DENMARK, KGS. Lyngby (DK)
Filed on Jun. 17, 2021, as Appl. No. 17/350,304.
Application 17/350,304 is a continuation of application No. 15/527,878, granted, now 11,065,201, previously published as PCT/EP2015/077282, filed on Nov. 20, 2015.
Claims priority of application No. 1451411-1 (SE), filed on Nov. 21, 2014.
Prior Publication US 2021/0386669 A1, Dec. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/06 (2006.01); A61K 9/00 (2006.01); A61K 47/26 (2006.01)
CPC A61K 9/06 (2013.01) [A61K 9/0024 (2013.01); A61K 47/26 (2013.01)] 17 Claims
 
1. A composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, wherein the composition is a liquid before administration and has the ability to transform into a gel-like material after administration, and wherein the composition comprises at least one active pharmaceutical ingredient which is a chemotherapeutic drug, an anti-infectious agent, or a combination thereof wherein the composition comprises at least one triglyceride in an amount of 10-50 wt % of the composition.