	US 12,226,507 B2
	Use of dianhydrohexitol in oral and dental care to reduce the development of bacterial strains
Clémentine Thabuis, Ledringhem (FR); Caroline Perreau, La Couture (FR); and Fabrice Desailly, Avion (FR)
Assigned to Roquette Freres, Lestrem (FR)
Appl. No. 16/764,711
Filed by ROQUETTE FRERES, Lestrem (FR)
PCT Filed Nov. 30, 2018, PCT No. PCT/FR2018/053059 § 371(c)(1), (2) Date May 15, 2020, PCT Pub. No. WO2019/106316, PCT Pub. Date Jun. 6, 2019.
Claims priority of application No. 1761521 (FR), filed on Dec. 1, 2017.
Prior Publication US 2021/0169766 A1, Jun. 10, 2021
Int. Cl. A61K 8/49 (2006.01); A61Q 11/00 (2006.01); A61Q 17/00 (2006.01)

CPC A61K 8/4973 (2013.01) [A61Q 11/00 (2013.01); A61Q 17/005 (2013.01); A61K 2800/74 (2013.01)]

15 Claims

1. A method for reducing the growth of at least two harmful oral bacterial strains in the buccal cavity, comprising the step of administering an antibacterial agent consisting of a dianhydrohexitol in combination with xylitol, to one in need thereof, wherein the dianhydrohexitol is chosen from isosorbide (1,4:3,6-dianhydrosorbitol), isomannide (1,4:3,6-dianhydromannitol), isoidide (1,4:3,6-dianhydroiditol) and mixtures of at least two of these compounds.