US 12,226,496 B2
Polymeric core-shell particles
Rachela Popovtzer, Givat Shmuel (IL); Chen Tzror-Azankot, Rishon Leztion (IL); and Menachem Motiei, Ashdod (IL)
Assigned to BAR-ILAN UNIVERSITY, Ramat Gan (IL)
Appl. No. 17/051,687
Filed by BAR-ILAN UNIVERSITY, Ramat Gan (IL)
PCT Filed Apr. 30, 2019, PCT No. PCT/IL2019/050480
§ 371(c)(1), (2) Date Oct. 29, 2020,
PCT Pub. No. WO2019/211843, PCT Pub. Date Nov. 7, 2019.
Claims priority of provisional application 62/664,302, filed on Apr. 30, 2018.
Prior Publication US 2021/0228750 A1, Jul. 29, 2021
Int. Cl. A61K 51/04 (2006.01); A61K 49/00 (2006.01); A61K 51/12 (2006.01)
CPC A61K 51/0482 (2013.01) [A61K 49/0002 (2013.01); A61K 51/0491 (2013.01); A61K 51/1234 (2013.01)] 18 Claims
 
1. A nanoparticle having a lipid core comprising a plurality of lipids, wherein said lipid core is linked via a first polymeric linker to a 2-Deoxy-D-Glucose (2-DG) molecule and is further linked via a second polymeric linker to a chelating agent; wherein a portion of the lipids attached to said 2-DG-molecules from said plurality of lipids is between about 5 and 20 mol %; wherein a portion of the lipids attached to the chelating agent from said plurality of lipids is between 2.4 and about 10 mol %; and wherein a hydrodynamic diameter of said nanoparticle is between 60 and 200 nm; wherein the first and the second polymeric linkers comprise PEG; and wherein said chelating agent is a metal chelator selected from the group consisting of: 1-(1,3-carboxy-propyl)-4,7,10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTAGA), 1-(1,2-carboxyethyl)-4,7,10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTASA) or 1,4,7,10-tetraazaacyclo-dodecane-1,4,7,10-tetra-acetic acid (DOTA), or any combination thereof.